The Nanocoulter particle size analyzer supplied by Guangzhou Jincheng Scientific Instrument Co., Ltd. utilizes the Coulter principle of resistive pulse sensing (RPS), enabling the acquisition of multidimensional data including particle size, concentration, zeta potential, and morphology in a single measurement. It features an audit trail function, storing complete pulse information for each particle, facilitating multi-angle analysis for research users.

The Nanocoulter particle size analyzer captures nanoparticle information and is applied in the detection of nanoparticles (concentration, particle size, zeta potential, morphology).

Coulter Principle:

Resistive Pulse Sensing (RPS)

There are two electrodes on either side of a chip pore in an electrolyte liquid. When voltage is applied and current passes through the small pore, an "electrical sensing zone" is generated around the pore. As each particle passes through the pore, it displaces an equivalent volume of conductive liquid, momentarily increasing the resistance in this electrical sensing zone and forming a voltage pulse. The instrument accurately measures and analyzes these electrical pulses to obtain multidimensional data such as particle size, concentration, zeta potential, and morphology.

Principle Advantages:

Single-particle detection, multidimensional detection of particle size, concentration, zeta potential, and morphology

Unaffected by sample absorbance and refractive index, independent of the sample's optical properties

Independent of Brownian motion of particles, unaffected by sample viscosity

No interference between particles, excellent testing performance for polydisperse samples

Extremely high resolution, capable of precisely observing subtle changes such as sample aggregation, fragmentation, and sedimentation

Application Areas:

Life Sciences: Exosome identification, virus quality control, liposome drug loading research, protein aggregation processes, condition changes in biopharmaceuticals, vaccine production, etc.

Coatings: Polymer coatings, lithium battery anode slurries, carbon dispersion systems, paints, inks, fuels, etc.

Chemical Engineering: Polymer microspheres, polishing slurries, emulsions, catalysts, micelle research, etc.

Nanomaterials: Research on the uniformity, solubility, and stability of organic and inorganic nanomaterials such as nano calcium carbonate, graphene, nano silicon, carbon dioxide, etc.

Instrument Features:

No calibration required

Foolproof operation, no warm-up needed, no calibration required

Simply scan the QR code on the detection card to complete all parameter settings

No cleaning required

Disposable non-invasive detection card

No need to clean the instrument and sample chamber before testing; directly load the sample to begin testing

Intelligent software

Audit trail function

Stores complete pulse information for each particle, facilitating multi-angle analysis for research users

Obtain multidimensional data including particle size, concentration, zeta potential, and morphology in a single measurement.

Single-particle detection

Real sample particles vary in size with a wide particle size distribution. The intensity of scattered light from particles is proportional to the sixth power of their size, so in optical detection methods, large particles can obscure the light signals of small particles, making it difficult to reflect the true situation. The new Nanocoulter particle size analyzer measures each particle passing through the pore individually, directly measuring the particle volume to determine size, eliminating mutual influence between large and small particles, accurately reflecting the true particle size distribution of the sample, and presenting the sample's original state to the user.

Particle size measurement comparable to electron microscopy

Directly measures particle volume, providing the most authentic particle size distribution data of the sample, consistent with particle size statistics from electron microscopy.

High accuracy, with particle size test data matching electron microscopy measurements, users can trust Nanocoulter.

Single-particle zeta potential measurement

The electrical charge of particles, i.e., their zeta potential, is a crucial parameter indicating the stability of dispersion systems. In electrolyte solutions, by detecting the time it takes for particles to pass through the nanopore and applying the Helmholtz-Smoluchowski equation, the zeta potential can be accurately calculated. Thus, Nanocoulter is the only technology capable of simultaneously measuring single-particle zeta potential, size, and concentration.

Accurate concentration measurement

The chip is equipped with molecular motors, ensuring stable sample flow through the pore. The number of particles detected per unit time directly gives the particle concentration, making it the most accurate and direct concentration detection method. Testing standard microspheres diluted to different multiples, the Nanocoulter particle size analyzer demonstrates excellent concentration measurement accuracy.

Good reproducibility of particle size and concentration data

Technical Parameters:

Information about the Nanocoulter particle size analyzer is provided by Guangzhou Jincheng Scientific Instrument Co., Ltd. For more details, please feel free to call for consultation.