Jiangsu Aikon, with years of deep expertise in the field of biochemical and chemical reagents, has earned consistent praise in the industry for its outstanding quality and professional services. We possess advanced production technology and our own warehouses, ensuring a comprehensive range of products and real-time inventory updates. Now, we support electronic payments for purchases, making your shopping experience more convenient. Choose Jiangsu Aikon for a guarantee of quality and service! Our products mainly cover: organic synthetic building blocks, pharmaceutical intermediates, general chemical reagents, and special chemicals, providing standard packaging from mg to kg levels to meet customer needs. The company's advantageous products include specialty heterocyclic compounds, PEG compounds, fluorine-containing compounds, chiral compounds, amino acids and their derivatives, boronic acids and their derivatives, etc.   

Summary of Pilot Scale-up Experience

The pilot testing phase involves further research into the variation patterns of chemical reaction conditions at a certain scale and addresses issues that cannot be resolved or discovered in the laboratory. Although the essence of chemical reactions does not change with different experimental productions, the optimal process conditions for each step of the chemical reactions may vary with external conditions such as experimental scale and equipment. Therefore, pilot scale-up is very important.

At what stage of the experiment should pilot testing be conducted? At least the following conditions must be met:

1. Stable yield in small-scale tests and reliable product quality;

2. Operating conditions have been determined, and analytical methods for products, intermediates, and raw materials have been established;

3. Corrosion resistance tests for certain equipment and pipeline materials have been conducted, and general required equipment is available;

4. Material balance calculations have been performed. Preliminary treatment methods for waste issues have been developed;

5. Specifications and unit consumption quantities of raw materials have been proposed;

6. Safety production requirements have been outlined.

Methods of Pilot Scale-up

Empirical Scale-up Method: Primarily relies on experience to explore reactor characteristics through step-by-step scaling (small-scale setup → pilot setup → medium-scale setup → large-scale setup).

Similarity Scale-up Method: Mainly applies the principle of similarity for scaling. This method has certain limitations and is only suitable for scaling physical processes, not chemical processes.

Mathematical Modeling Scale-up Method: Utilizes computer technology for scaling and represents the future direction of development.

Additionally, the development of micro pilot setups is progressing rapidly, where micro pilot setups replace large pilot setups to provide precise design data for industrial-scale equipment. The advantages include low cost and fast construction.

Thank you for your attention and support of Jiangsu Aikon. We look forward to cooperating with you for mutual development.